Liquid BioCell® PURE: the cleanest, simplest form of the patented Collagen/HA Matrix®
60-Second Verdict
PURE is the minimalist Liquid BioCell variant — just the multi-patented Collagen/HA Matrix® (hydrolysed type II collagen + chondroitin sulfate + hyaluronic acid, made from chicken cartilage), naturally flavoured with stevia. No sugar, no carbs, no calories, no added superfoods. NSF Certified for Sport®, so it’s tested clean for athletes and tested clean for everyone else too. One tablespoon daily, 30 servings per bottle. The choice when you want pure technology without any of the extras — or when you’re stacking with other supplements and don’t want overlapping ingredients.
★★★★★
The patented Collagen/HA Matrix® — not just collagen peptides
Most collagen supplements give you collagen peptides alone. Liquid BioCell delivers all three components of your connective tissue in their native ratio: 60% hydrolysed type II collagen, 20% chondroitin sulfate, 10% hyaluronic acid. The matrix is the patent — not the collagen itself.
★★★★★
Zero sugar. Zero carbs. Under 10 kJ per serve.
Most flavoured liquid collagens hide 5–15 grams of sugar per serve. PURE has none. Naturally sweetened with steviol glycosides (stevia leaf extract). Suitable for keto, low-carb, diabetic-aware, and intermittent fasting routines.
★★★★★
NSF Certified for Sport®
PURE carries the NSF Certified for Sport® mark — meaning every batch is third-party tested for banned substances on the WADA list. Required by elite athletes; reassuring for everyone else. Few liquid collagens carry this certification.
Why ‘just collagen peptides’ isn’t enough — and what makes the Matrix different
Your joints, skin, and connective tissue aren’t made of collagen alone. They’re made of a specific ratio of three substances: type II collagen, hyaluronic acid, and chondroitin sulfate — the same ratio found naturally in healthy cartilage. From your mid-20s onwards, your body starts producing less of all three. By 50, you’re making about half of what you made at 25. Most collagen supplements only address one of these — they give you collagen peptides and assume your body can rebuild the rest. For many people that works fine. For others, especially those already feeling joint stiffness or noticing skin dryness, it doesn’t.
Liquid BioCell® takes a different approach. Rather than just peptides, it delivers the full Collagen/HA Matrix® — collagen, hyaluronic acid, and chondroitin sulfate in their native 60/20/10 ratio, made from chicken cartilage. The molecules are hydrolysed (broken down) using Bio-Optimized™ processing to a molecular weight your body absorbs efficiently — no fillers, binders, or capsule coatings to slow it down. PURE is that matrix in its cleanest form: no added superfoods, no added vitamins, no sugar, no calories. Just the molecules your body uses to rebuild connective tissue — nothing else.
What’s in each 15 mL serve of PURE
PURE’s short ingredient list is by design. The hero work is done by the Collagen/HA Matrix® itself.
| Ingredient | Role | What it does |
|---|---|---|
| Purified water | Solvent base | Purified by reverse osmosis and deionisation. Forms the liquid delivery system that gives Liquid BioCell its absorption advantage over capsules. |
| Hydrolysed type II collagen (Liquid BioCell®) | 3.5% w/w | The patented Collagen/HA Matrix® itself, from chicken cartilage (Gallus gallus). Contains 60% hydrolysed collagen peptides + 20% chondroitin sulfate + 10% hyaluronic acid — the same ratio found in healthy human articular cartilage. Bio-Optimized™ molecular weight for efficient absorption. |
| Malic acid | Acidity regulator | Preserves the freshness and stability of the liquid matrix. Naturally derived from apples and grapes. |
| Natural flavour | Taste | Naturally derived fruit flavouring. No artificial flavours or colours. |
| Steviol glycosides (stevia extract) | Sweetener | Zero-calorie plant-derived sweetener from the stevia leaf. Provides taste without sugar, carbs, or kilojoules. |
| Sodium benzoate | Preservative | Food-grade preservative used at very low levels to maintain product safety throughout shelf life. Required because the liquid format is more shelf-sensitive than capsules. |
PURE vs LIFE vs SKIN: which Liquid BioCell variant suits you?
All three contain the same Collagen/HA Matrix® in the same amount. The difference is what’s added around it — and that determines who each variant is for.
| Criterion | Liquid BioCell® PURE | Liquid BioCell® LIFE / SKIN |
|---|---|---|
| Core ingredient | Collagen/HA Matrix® only | Collagen/HA Matrix® + added superfoods (10 in LIFE, 19 in SKIN) + added vitamin C (SKIN) |
| Sugar / carbs / calories | Zero / zero / <10 kJ per serve | LIFE: ~12 g sugar from fruit juices, ~210 kJ. SKIN: similar profile to LIFE. |
| Sweetener | Stevia (natural, zero-calorie) | Combination of fruit juice concentrates + small amount of stevia |
| Gluten-free | Yes | LIFE: yes. SKIN: NO — SKIN contains a wheat extract (phytoceramides) |
| Keto / low-carb friendly | Yes | No — LIFE and SKIN contain fruit-derived sugars |
| NSF Certified for Sport® | Yes | LIFE and SKIN: no |
| Best for… | Purists, keto/low-carb, athletes, anyone stacking multiple supplements | People who want broader nutritional support (LIFE) or a targeted skin focus (SKIN) |
| Member price (AUD) | $99.95 | LIFE: $99.95. SKIN: $105.45 |
What to expect: a realistic timeline with Liquid BioCell® PURE
Liquid BioCell works at the cellular level — rebuilding cartilage and supporting hyaluronic acid stores in your body. That doesn’t happen in days. Here’s the honest curve.
Weeks 1–3
Most people notice nothing dramatic in the first three weeks. Your body is absorbing the collagen peptides, chondroitin and hyaluronic acid and beginning to deploy them into connective tissue — but visible or felt change takes longer. Don’t judge it yet.
Weeks 4–8
This is when most users start reporting the first noticeable changes. Skin hydration is typically the first signal — cheeks and the back of hands feeling less dry. Some users report less morning joint stiffness, particularly in knees and fingers. Hair and nails often look stronger — nails growing faster and less prone to splitting.
Weeks 8–12 and beyond
Published research on BioCell Collagen® consistently uses 8–12 weeks as the trial window. This is where the most measurable changes appear: skin elasticity, reduction in visible fine lines, joint comfort during activity. The key is consistency — missing two days here and there is fine, but the benefit compounds with daily use.
Is Liquid BioCell® PURE right for you?
✓ Yes if you…
- You want the patented Collagen/HA Matrix® without added sugar, fruit juices or extras
- You’re keto, low-carb, intermittent fasting, or just sugar-conscious
- You’re an athlete or active adult and value the NSF Certified for Sport® mark
- You already take other supplements (multivitamin, antioxidant, greens) and don’t want overlap
- You’re starting your first collagen and want the cleanest baseline to judge results against
✕ Skip if you…
- You’re vegetarian or vegan — PURE uses chicken cartilage as the collagen source
- You have a known chicken or egg allergy — talk to your GP first
- You’re pregnant or breastfeeding — collagen supplements aren’t tested for this population; talk to your GP
- You want a single product that also covers antioxidants, vitamins and superfoods — look at LIFE or SKIN
- You’re looking for a vegan plant-based collagen-builder — this isn’t it (true collagen comes from animal sources)
Three pro tips for getting the most from PURE
Take it on an empty stomach in the morning
Liquid BioCell absorbs faster than capsule collagen, and that absorption is fastest when there’s no competing food in your stomach. First thing in the morning — before your coffee or breakfast — gives the peptides a clear runway. If mornings are chaotic, second-best is mid-afternoon, well before dinner.
Pair it with vitamin C from food, not a tablet
Vitamin C is a cofactor in your body’s collagen-building process. PURE doesn’t include vitamin C (SKIN does), which means you’ll want some in your diet that day. A kiwi fruit, half a capsicum, or a small glass of orange juice with breakfast does it. You don’t need a tablet.
Don’t mix it into hot drinks
Heat above 60°C can degrade hydrolysed collagen peptides over time. A splash into room-temperature water or your morning smoothie is fine. Stirring it into a piping-hot coffee or tea — less fine. If you want a warm vehicle, wait until your drink has cooled to lukewarm.
The published research behind Liquid BioCell®
Meet the creator
Asma Ishaq — creator of Liquid BioCell®, now head of Shaklee’s Liquid Collagen division
Asma Ishaq is the scientist and entrepreneur behind Liquid BioCell®. She spent over two decades building the ingestible collagen category from a niche idea into a global industry — previously as CEO of Modere, where she positioned the brand at the forefront of clean-label wellness, and as inaugural Chairperson of the Collagen Stewardship Alliance.
In July 2025, when Shaklee acquired Modere’s products and intellectual property, Ishaq joined the Shaklee executive team as head of the newly-formed Liquid Collagen Acquisition Corporation. The Liquid BioCell range — PURE, LIFE, SKIN and Pet — is now under her direct stewardship at Shaklee.
“Seventeen years ago, I took a leap of faith — selling my first bottle of Liquid BioCell with the hope of creating something meaningful. What began as a way to support my daughter as a single mom turned into a global mission to bring innovative, science-backed wellness to the world.” — Asma Ishaq, Shaklee press release, 29 July 2025
- Joint mobility & comfort: A clinical study on BioCell Collagen® demonstrated improvements in joint mobility and measurable improvement in joint discomfort scores over 8 weeks of daily supplementation (Schauss et al., published research; PubMed 26770145).
- Skin hydration, dryness & fine lines: A randomised, double-blind, placebo-controlled trial of BioCell Collagen® found significant reductions in skin dryness and improvements in fine line appearance after 12 weeks of daily use.
- Hyaluronidase inhibition: Liquid BioCell® has been scientifically shown to inhibit hyaluronidase — the enzyme that breaks down your body’s own hyaluronic acid and contributes to the visible signs of ageing.
- Collagen synthesis stimulation: Hydrolysed collagen (the form used in Liquid BioCell®) has been shown in research to stimulate chondrocytes — the cells responsible for synthesising type I, II and III collagen — supporting your body’s own collagen production (PubMed 22956862).
- Bio-Optimized™ molecular weight: Liquid BioCell® uses a patented manufacturing process to produce collagen peptides at a molecular weight optimised for absorption — the rationale for the liquid format over capsules or powders.
- Patent & awards: The Collagen/HA Matrix® technology is protected by 7 US and international patents, and has been recognised with “Best Bone and Joint Health Ingredient” from Frost & Sullivan and SupplySide West.
- BioCell® and Liquid BioCell® are registered trademarks of Biocell Technology LLC, Newport Beach, California.
Always read the label and follow the directions for use. If symptoms persist, talk to your health professional.
Frequently asked questions about Liquid BioCell® PURE
How is PURE different from LIFE and SKIN?
Same Collagen/HA Matrix® in all three, in the same amount. PURE has nothing added — no superfoods, no extra vitamins, no fruit juices, no sugar. LIFE adds 10 superfoods plus resveratrol. SKIN adds 19 superfoods plus vitamin C plus phytoceramides for beauty-focused benefits. Choose PURE if you want the science without the extras, or if you’re keto.
How does Liquid BioCell compare to Vivix or Collagen-9?
Different products for different goals. Vivix is a polyphenol antioxidant — not a collagen product. Collagen-9 is a powdered collagen with nine collagen types but no Collagen/HA Matrix® technology and no chondroitin or hyaluronic acid. Liquid BioCell PURE is the liquid Matrix® in its cleanest form. Many customers stack Vivix (cellular antioxidant) with Liquid BioCell (connective tissue) for complementary benefits.
How long until I see results?
Most users report first changes (skin hydration, nail strength) around weeks 4–6. The published clinical trials on BioCell Collagen® ran for 12 weeks — so think of three months as the realistic evaluation window. Results compound with consistency.
Why is Liquid BioCell more expensive than collagen powder?
Three reasons: the Collagen/HA Matrix® technology is patent-protected (not just collagen peptides); the liquid format costs more to manufacture and ship than powder; and the bio-optimised molecular weight requires a more involved hydrolysis process. Whether that’s worth it depends on your priorities — absorption speed, convenience, the Matrix® vs peptides alone.
Is it safe in pregnancy or with medications?
Liquid BioCell hasn’t been specifically studied in pregnant or breastfeeding women — the standard supplement advice applies: talk to your GP or pharmacist before starting. If you’re on prescription medication, particularly blood thinners or immunosuppressants, also worth checking. Most healthy adults take it without any interaction concerns.
Is PURE vegan, gluten-free, or kosher?
PURE is NOT vegan or vegetarian — it uses chicken cartilage as the collagen source (this is unavoidable with true type II collagen). It IS gluten-free, dairy-free, and non-GMO. Always check the current label for the most up-to-date allergen information.
How do I take it — straight or mixed?
Label dose: one tablespoon (15 mL) daily, with or without food. Many users take it straight off the spoon — it’s pleasantly flavoured. If you prefer, mix into a small glass of cold or room-temperature water, juice, or smoothie. Avoid hot drinks (heat degrades collagen peptides). Refrigerate after opening; use within 30 days for maximum potency.
Is it covered by the money-back guarantee?
Yes — 100% money-back guarantee, even if the bottle is used. Shaklee has stood behind this guarantee for over 70 years.
Pricing & Member Perks
Retail price: $117.60 | Member price: $99.95. Save $17.65. Prices in AUD, GST Included.
Save 15% with customer membership — free with first order of $50+
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